Structure of PDB 7m0e Chain A Binding Site BS01

Receptor Information
>7m0e Chain A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALK
SFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLEL
FSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERM
PREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDG
RSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHR
RLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAGR
VLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7m0e Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		W274 N467 R514 R517 K521 L527 E529 H530
Binding residue
(residue number reindexed from 1)		W37 N230 R277 R280 K284 L290 E292 H293
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7m0e, PDBe:7m0e, PDBj:7m0e
PDBsum7m0e
PubMed35778389
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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