Structure of PDB 7m07 Chain A Binding Site BS01

Receptor Information
>7m07 Chain A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKS
FHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELF
SNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMP
REEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGR
SHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR
LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVPG
RVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7m07 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining.
Resolution1.57 Å
Binding residue
(original residue number in PDB)		W274 V462 S463 Q464 Q471 K472 R514 R517 K521 L527 S528 E529 H530
Binding residue
(residue number reindexed from 1)		W36 V224 S225 Q226 Q233 K234 R276 R279 K283 L289 S290 E291 H292
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7m07, PDBe:7m07, PDBj:7m07
PDBsum7m07
PubMed35778389
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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