Structure of PDB 7lyu Chain A Binding Site BS01

Receptor Information
>7lyu Chain A (length=364) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EINPSQLVDTFEENWSFYPNAVRTAGFCGNPSFHLYWPNKKTHNALSSRE
LIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLP
SSSNSIGCSPFQFHEATIYNAVNSSSWKRITIQLPDHVSSSATQFRWIQK
EKQSWAIDHVYIGEACPKLCSGHGYCTTGAVCICDESFQGDDCSVFSHEL
PSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSLYFNGCQIR
QAATKPLDLTRASKIMFVLQIGSPAQTDSCNSDLSGPHTVDKAVLLQYSV
NNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGH
DQWALDHVEVVLVS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7lyu Chain A Residue 3501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7lyu Structure of Reelin repeat 8 and the adjacent C-terminal region.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T3062 S3091 D3224
Binding residue
(residue number reindexed from 1)		T10 S32 D158
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0070325 lipoprotein particle receptor binding
Biological Process
GO:0001764 neuron migration
GO:0007417 central nervous system development

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lyu, PDBe:7lyu, PDBj:7lyu
PDBsum7lyu
PubMed35659645
UniProtQ60841|RELN_MOUSE Reelin (Gene Name=Reln)

[Back to BioLiP]