Structure of PDB 7lwa Chain A Binding Site BS01

Receptor Information
>7lwa Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSPMERFHLKYLYVTDLAEQNWCELQTAYGKELPGPVTTKEDAWAIKFLN
ILLLIPTLQSEGHIREFPVFGEVEGVLLVGVIDELHYTAKGELELAELKT
RRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIHHTKLCLEKP
LGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQET
ATVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYA
DICEWRKG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lwa EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		Y82 V83 T84 E196 K198 Q217 Y221
Binding residue
(residue number reindexed from 1)		Y13 V14 T15 E97 K99 Q118 Y122
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004527 exonuclease activity
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lwa, PDBe:7lwa, PDBj:7lwa
PDBsum7lwa
PubMed34197737
UniProtQ9H790|EXO5_HUMAN Exonuclease V (Gene Name=EXO5)

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