Structure of PDB 7lvz Chain A Binding Site BS01

Receptor Information

>7lvz Chain A (length=236) Species: 10090 (Mus musculus)

ASLIQRIARQACLTFRPAPGFPENLSLLKSLLTQVRAEDLNIAPRKALPQ
PLPRNLPPVTYMHIYETEGFSLGVFLLKSGTCIPLHDHPGMHGMLKVLYG
TVRISCMDKLDTGAGHRRPPPEQQFEPPLQPLEREAVRPGVLRSRAEYTE
ASGPCVLTPHRDNLHQIDAVDGPAAFLDILAPPYDPEDGRDCHYYRVVEP
IRPACDLPREVWLLETPQADDFWCEGEPYPGPKVLP

Ligand information

• Ligand ID: FE2
• InChI: InChI=1S/Fe/q+2
• InChIKey: CWYNVVGOOAEACU-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Fe+2]
  CACTVS 3.341: [Fe++]
• Formula: Fe
• Name: FE (II) ION
• DrugBank: DB14510
• PDB chain: 7lvz Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lvz The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme.
• Resolution: 1.89 Å
• Binding residue (original residue number in PDB): H100 H102 H179
• Binding residue (residue number reindexed from 1): H86 H88 H165
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.13.11.19: cysteamine dioxygenase.

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005515 protein binding
• GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• GO:0046872 metal ion binding
• GO:0047800 cysteamine dioxygenase activity
• GO:0051213 dioxygenase activity

Biological Process

• GO:0071456 cellular response to hypoxia

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:7lvz, PDBe:7lvz, PDBj:7lvz
• PDBsum: 7lvz
• PubMed: 34762398
• UniProt: Q6PDY2|AEDO_MOUSE 2-aminoethanethiol dioxygenase (Gene Name=Ado)