Structure of PDB 7luf Chain A Binding Site BS01

Receptor Information
>7luf Chain A (length=1044) Species: 10298 (Human alphaherpesvirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCG
GDERDVLRVGSGGFWPRRSRLWGGVDHAPAGFNPTVTVFHVYDILENVEH
AYGMRAAQFHARFMDAITPTGTVITLLGLTPEGHRVAVHVYGTRQYFYMN
KEEVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFEAEVVERTDV
YYYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDATTRFILDNP
GFVTFGWYRLKPGRNNTLAQPRAPMAFGTSSDVEFNCTADNLAIEGGMSD
LPAYKLMCFDIACKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEH
VLLFSLGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYG
PEFVTGYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVFRVWDIGQSH
FQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKKDLSYR
DIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGIN
ITRTIYDGQQIRVFTCLLRLADQKGFILPDTQVGYQGARVHDPTSGFHVN
PVVGFDFASLYPSIIQAHNLCFSTLSLRADAVAHLEAGKDYLEIEVGGRR
LFFVKAHVRESLLSILLRDWLAMRKQIRSRIPQSSPEEAVLLDKQQAAIK
VVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREYVHARWAAFEQ
LLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAMGDKMAS
HISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKN
NCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLARPLPEGLQAFG
AVLVDAHRRITDPERDIQDFVLTAELSRHPRAYTNKRLAHLTVYYKLMAR
RAQVPSIKDRIPYVIVAQTREVEETVARLAALRELVSELAEDPAYAIAHG
VALNTDYYFSHLLGAACVTFKALFGNNAKITESLLKRFIPEVWH
Ligand information
Receptor-Ligand Complex Structure
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PDB7luf Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		Q510 Q618 Q640 G695 Y696 Q697 G698 R700 V701 L827 K938 K940 V1139 S1140 H1164 V1171
Binding residue
(residue number reindexed from 1)		Q452 Q560 Q582 G584 Y585 Q586 G587 R589 V590 L716 K827 K829 V986 S987 H1011 V1018
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0042025 host cell nucleus
GO:0042575 DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7luf, PDBe:7luf, PDBj:7luf
PDBsum7luf
PubMed34031403
UniProtP04293|DPOL_HHV11 DNA polymerase catalytic subunit (Gene Name=UL30)

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