Structure of PDB 7lt2 Chain A Binding Site BS01

Receptor Information
>7lt2 Chain A (length=387) Species: 7070 (Tribolium castaneum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENILNDINKRFISLPEEDVRGNKQILESVLRTFVEQMKTQDPLFKALFRR
VFYGGSFYDGLKVGKPEEFDLDILLHIPIYAQPVLNESNVPGFVWLKLNN
LDGWLRQPEGRVYKDFRKKFLADNDFLDTGKTLRWMESLVQKTLNTLPWV
NNATCELTNEFGTFHINWWKGGPAMTLGISHSSGEKIMDVDLVACFVFSG
DKWPINGYRSNPFPSTKPEFFIVPKKPPVNPQGRYWSLSFQEQERVLIDN
KNRLKPAVKLIKKLKEKTHPNIASYYIKTVFLHIIEQKDQSFWNKSLREV
FMTTLREYNEFIADQSIPYYWCRKNNLIGHLAPITLNNISNRIGYIIKDI
ENNPENIAKHLLTKEEYTKYIQGEDVMAEALPALPAS
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7lt2 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7lt2 cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
Resolution1.58 Å
Binding residue
(original residue number in PDB)		I289 E290 K292
Binding residue
(residue number reindexed from 1)		I285 E286 K288
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0140700 3',2'-cyclic GMP-AMP synthase activity
Biological Process
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:1902615 immune response involved in response to exogenous dsRNA

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lt2, PDBe:7lt2, PDBj:7lt2
PDBsum7lt2
PubMed34261127
UniProtD6WI29|CGLR_TRICA Cyclic GMP-AMP synthase-like receptor (Gene Name=TcasGA2_TC003965)

[Back to BioLiP]