Structure of PDB 7ls2 Chain A Binding Site BS01

Receptor Information
>7ls2 Chain A (length=61) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGFDSRGKREFDRHSGSDRSGLKHEDKRGGSGSHNWGTVKDELTDLDQST
LDEWKAIQNKD
Ligand information
>7ls2 Chain m2 (length=1724) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugaccccccuucccggggggg
gaugcgugcauuuaucagauggugacucuagauaaccucgggccgaucgc
acgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuu
ucgaugguagucgccgugccuaccauggugaccacgggugacggggaauc
aggguucgauuccggagagggagccugagaaacggcuaccacauccaagg
aaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugac
gaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguc
cacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccag
cagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguu
aaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggcg
gggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccg
agccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucua
uuuuguugguuuucggaacugaggccaugauuaagagggacggccggggg
cauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacgg
accagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaa
gucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacg
augccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcu
uccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcu
gaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcgg
cuuaauuugacucaacacgggaaaccucacccggcccggacacggacagg
auugacagauugauagcucuuucucgauuccgugggugguggugcauggc
cguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacga
gacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccc
caacuucuuagagggacaaguggcguucagccacccgagauugagcaaua
acaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacug
acuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguu
gaaccccauucgugauggggaucggggauugcaauuauuccccaugaacg
aggaauucccaguaagugcgggucauaagcuugcguugauuaagucccug
cccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugag
gcccucggaucggccccgccggggugcccuggcggagcgcugagaagacg
gucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccgua
ggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<...<....<<....<<..........>>...>>.>.......<<...
.....<<<.<.<..<<....<<<<<.........<<..<...<..<....
...>..>......>>>.........<<<<...<<<<<<<....>>>>>>>
...>>>><<..<<<<<....<......>..>>>>>......>>...<<<<
.<<<<......>>>>>>>>.>>.>>>...>>>.>.>>>.<<<....<<<.
.....<<<<<.........>>>>>..>>>......>>>...<<<.<<<<.
...>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>
>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...
>>.>.....<<<<<<<<<.<<.......>>.>>>>>.>>>>......<<.
.<...........>..>>.........<<<<<((......<<<<.....<
<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((
.....<.<<...<<<.............<<<..>>>.....<..<.....
.......>.>...<<<<<<.<.......<<...<.......>..<<....
.....>.>...>>......>.>>>..>>>........<.<..<<<<<<<.
..............>>>>>>>..>.>..........<<<<<<..<...<<
<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.
......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....
<<<<<<....<...<<<<.........>>>>...>.>>>>>>........
..<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>
...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<
<......<<........>>..........<<<<<......<<<<<.....
...<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<
<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>..
..<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>....
.>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>
>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.>...<
<.<<<........<.......<<<<<<<<....>>>>>>>>....>....
.....>>>.>>............<<<<<..........>>>>>.......
....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>
>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...
<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>
>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<
<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ls2 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R188 R191 F193 D194 R195 H196 G198 R201 G203 L204 K205 K209 R210 S213 G214 H216
Binding residue
(residue number reindexed from 1)		R6 R9 F11 D12 R13 H14 G16 R19 G21 L22 K23 K27 R28 S31 G32 H34
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0030371 translation repressor activity
GO:0032183 SUMO binding
GO:0043022 ribosome binding
GO:0061770 translation elongation factor binding
Biological Process
GO:0006417 regulation of translation
GO:0017148 negative regulation of translation
GO:0030578 PML body organization
GO:0141014 ribosome hibernation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ls2, PDBe:7ls2, PDBj:7ls2
PDBsum7ls2
PubMed34815424
UniProtQ9CY58|SERB1_MOUSE SERPINE1 mRNA-binding protein 1 (Gene Name=Serbp1)

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