Structure of PDB 7lrm Chain A Binding Site BS01

Receptor Information
>7lrm Chain A (length=553) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL
KKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLP
QGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRET
KLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTNSQ
YALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lrm Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		F61 L74 D76 R78 E89 I94 Q151 G152 K154 P157 Y183 D185 M230 G231 Q258 K259 G262 K263 W266 S280 R284 G285 K353 R358 G359 A360 H361 R448 T473 Q475 K476 Y501
Binding residue
(residue number reindexed from 1)		F61 L74 D76 R78 E89 I94 Q151 G152 K154 P157 Y183 D185 M230 G231 Q258 K259 G262 K263 W266 S280 R284 G285 K353 R358 G359 A360 H361 R448 T473 Q475 K476 Y501
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7lrm, PDBe:7lrm, PDBj:7lrm
PDBsum7lrm
PubMed35218925
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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