Structure of PDB 7lre Chain A Binding Site BS01

Receptor Information
>7lre Chain A (length=502) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCAL
LNSGGGVIKAEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGN
YFLIFVKSWSLNTSGLRITTLSSNLYKRDITSAKVMNATAALEFLKDMKK
TRGRLLAKRPCVDIQEENNMKALAGVFFDRTELDRKEKLTFTESTHVEIK
NFSTEKLLQRIKEILPQYVSAFANTDGGYLFIGLNEDKEIIGFKAEMSDL
DDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCGYVCALRV
ERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAERITYTPENLCRK
LFLQHEGLKQLICEEMDSVRKGSLIFSRSWSVDLGLQENHKVLCDALLIS
QDSPPVLYTFHMVQDEEFKGYSTQTALTLKQKLAKIGGYTKKVCVMTKIF
YLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKRLKSLRDQF
SF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7lre Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7lre Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		H275 C311 C312
Binding residue
(residue number reindexed from 1)		H268 C304 C305
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0043022 ribosome binding
Biological Process
GO:0016075 rRNA catabolic process
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lre, PDBe:7lre, PDBj:7lre
PDBsum7lre
PubMed34272366
UniProtQ8IYM2|SLN12_HUMAN Ribonuclease SLFN12 (Gene Name=SLFN12)

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