Structure of PDB 7lp9 Chain A Binding Site BS01

Receptor Information

>7lp9 Chain A (length=634) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DRRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAM
LNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERR
NMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLA
IVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEI
LILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPEC
RHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDM
LLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPP
YKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYS
EILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQM
GIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKGNSYNSLYS
TCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALM
GETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTP
DGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNC

Ligand information

Ligand ID

T7X

InChI

InChI=1S/C47H83O13P/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)59-39(38-58-61(55,56)60-47-45(53)43(51)42(50)44(52)46(47)54)37-57-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,17,19,22,24,28,30,39,42-47,50-54H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,55,56)/b13-11+,19-17+,24-22-,30-28-/t39-,42-,43-,44+,45-,46-,47-/m1/s1

InChIKey

KRTOMQDUKGRFDJ-TWUHCGEESA-N

SMILES

Software	SMILES
CACTVS 3.385	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P](O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)OC(=O)CCC\C=C/C/C=C\C/C=C/C/C=C/CCCCC
OpenEye OEToolkits 2.0.4	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
CACTVS 3.385	CCCCCCCCCCCCCCCCCC(=O)OC[CH](CO[P](O)(=O)O[CH]1[CH](O)[CH](O)[CH](O)[CH](O)[CH]1O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
OpenEye OEToolkits 2.0.4	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OC1[C@@H]([C@H](C([C@H]([C@H]1O)O)O)O)O)OC(=O)CCC/C=C\C/C=C\C/C=C/C/C=C/CCCCC
ACDLabs 12.01	C1(C(C(C(C(C1O)O)O)O)O)OP(OCC(OC(CCCC=[C@H]CC=[C@H]C[C@H]=CC\C=C\CCCCC)=O)COC(=O)CCCCCCCCCCCCCCCCC)(O)=O

Formula

C47 H83 O13 P

Name

Phosphatidylinositol

PDB chain

7lp9 Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7lp9 Heat-dependent opening of TRPV1 in the presence of capsaicin.
Resolution	2.63 Å
Binding residue (original residue number in PDB)	R409 D509 Y511 S512 L515 L553 R557 E570
Binding residue (residue number reindexed from 1)	R297 D397 Y399 S400 L403 L441 R445 E458
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004888	transmembrane signaling receptor activity
GO:0005216	monoatomic ion channel activity
GO:0005230	extracellular ligand-gated monoatomic ion channel activity
GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity
GO:0005261	monoatomic cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0008324	monoatomic cation transmembrane transporter activity
GO:0015276	ligand-gated monoatomic ion channel activity
GO:0015278	intracellularly gated calcium channel activity
GO:0017081	chloride channel regulator activity
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051219	phosphoprotein binding
GO:0097603	temperature-gated ion channel activity

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0001659	temperature homeostasis
GO:0001660	fever generation
GO:0001774	microglial cell activation
GO:0002024	diet induced thermogenesis
GO:0002790	peptide secretion
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006629	lipid metabolic process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009268	response to pH
GO:0009408	response to heat
GO:0010459	negative regulation of heart rate
GO:0010917	negative regulation of mitochondrial membrane potential
GO:0014047	glutamate secretion
GO:0014832	urinary bladder smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0019722	calcium-mediated signaling
GO:0034220	monoatomic ion transmembrane transport
GO:0034605	cellular response to heat
GO:0043065	positive regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0050909	sensory perception of taste
GO:0050954	sensory perception of mechanical stimulus
GO:0050955	thermoception
GO:0050960	detection of temperature stimulus involved in thermoception
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0051289	protein homotetramerization
GO:0055085	transmembrane transport
GO:0060079	excitatory postsynaptic potential
GO:0060083	smooth muscle contraction involved in micturition
GO:0070588	calcium ion transmembrane transport
GO:0071312	cellular response to alkaloid
GO:0071318	cellular response to ATP
GO:0071345	cellular response to cytokine stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0071468	cellular response to acidic pH
GO:0071502	cellular response to temperature stimulus
GO:0090212	negative regulation of establishment of blood-brain barrier
GO:0098703	calcium ion import across plasma membrane
GO:1901594	response to capsazepine
GO:1990090	cellular response to nerve growth factor stimulus

	Cellular Component
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0032591	dendritic spine membrane
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0098982	GABA-ergic synapse

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7lp9, PDBe:7lp9, PDBj:7lp9
PDBsum	7lp9
PubMed	34239123
UniProt	O35433\|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (Gene Name=Trpv1)

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