Structure of PDB 7lp3 Chain A Binding Site BS01
Receptor Information
>7lp3 Chain A (length=37) Species:
9606
(Homo sapiens) [
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PHMPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL
Ligand information
>7lp3 Chain B (length=14) Species:
9606
(Homo sapiens) [
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EHRGPPPEYPFKGM
Receptor-Ligand Complex Structure
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PDB
7lp3
Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
Resolution
1.61 Å
Binding residue
(original residue number in PDB)
R208 Y210 V212 H214 R217 T218 T219 Q220 W221
Binding residue
(residue number reindexed from 1)
R19 Y21 V23 H25 R28 T29 T30 Q31 W32
Enzymatic activity
Enzyme Commision number
2.3.2.26
: HECT-type E3 ubiquitin transferase.
2.3.2.36
: RING-type E3 ubiquitin transferase (cysteine targeting).
External links
PDB
RCSB:7lp3
,
PDBe:7lp3
,
PDBj:7lp3
PDBsum
7lp3
PubMed
34284061
UniProt
Q96PU5
|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)
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