Structure of PDB 7lok Chain A Binding Site BS01

Receptor Information

>7lok Chain A (length=363) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQ
EIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVNCNTS
AITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTH
GIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRP
NIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTH
SFNCGGEFFYCNTSGLFNSTWISDSITLPCRIKQIINMWQRIGQAMYAPP
IQGVIRCVSNITGLILTRDGGSTTETFRPGGGDMRDNWRSELYKYKVVKI
EPLGVAPTRCKRR

Ligand information

>7lok Chain G (length=27) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

CNLHFCQLRCKSLGLLGRCAPTYCACV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7lok Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation.
Resolution	3.9 Å
Binding residue (original residue number in PDB)	A281 S365 G366 D368 E370 N425 R429 I430
Binding residue (residue number reindexed from 1)	A182 S241 G242 D244 E246 N287 R291 I292

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Cellular Component
GO:0019031	viral envelope

View graph for
Cellular Component

External links

PDB	RCSB:7lok, PDBe:7lok, PDBj:7lok
PDBsum	7lok
PubMed	33782388
UniProt	Q2N0S6

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