Structure of PDB 7lo5 Chain A Binding Site BS01

Receptor Information
>7lo5 Chain A (length=1016) Species: 980427 (Deinococcus wulumuqiensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLQLVKKFQKRLEDIVAYGGTRNESSVRAAFQQLLSDWAEGSGLRLITEV
TQKAVAGNNVRPDGTLKDSLQQSRGYWESKDEADTLDDEIQKKLAKGYPR
DNIIFEDSRLAVLMQNGEEVQRVDMGDAGALAGLLKLFFEFEPPQVLEFR
KAVDHFKDEMPHLLKILREAADAAEQKADYRGERDHFVEIAKEAINPDFS
PRDAREMLIQHILTGDLFTSVFDNAQYHEDNNIAQQLQQLAATFYKGPVK
RDIAERTKRYYGAIQAAAAQIADHHEKQRFLKALYENFYRAYNPAGAERL
GIFYTPGEIVRFMIEATDTLLEKHFQKELADKGVEILDPATGTGTFITEL
IDFLPKAKLEQKYREELHCNELALLPYYIANLNIEATYAQKMGRYEEFRN
IVLVDTLDNTGFSGLFGSVTAENLERAKRQNARPVRVIIGNPPYRANQAN
ENDNNKNREYKEIDRRIKATYVAASTAQKTKLYDMYSRFLRWATDRLKED
GIVAFVSNSSFIDSRTFDGFRKEVVKDFDHIYILDMKGNANTSGERRKRE
GGNVFNDQIKVGVAVYFLVRSAKDTKIWYHAVPDFWRAREKLEWLKTTKF
EDIEFDHIRPDAKHNWLGQVDEENDWNEFLPVADKDTKQAKGLGQERAIF
KLYSLGVVTNRDEWVYSRAEDELADKVRYFIGRYNEIIKLPLGDLMSRNW
EGDIKMTRATIADAQSRKSYSLEKNSIVPSLYRPFDVLKMYFSKNLNEMQ
YQMPSIFPKGVGENVVIALSGSPAAKPFQVLATDILPSLDLLEKTQCLPF
YRYTMNGERLNNITDYALKAFQTHYADTSISREDIFHYVYAVLHHPAYRE
KYALNLRQEFPRIPFYPEFGRWAAWGRELMALHIGFESVAPYPLKRTDEP
PKNDTPEALALAKKARLKVQRDAAKQPTGAVELDGLTTLAGIPAAAWAYK
LGNRSALEWVLERHKETTPKDATIREKFNTYRFADHKERVIDLLARVTTV
SVETVRIVGEMPAETM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lo5 Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		F304 N448 Y451 A484 Q485 K486 K488 N515 S521 R522 T523 F562 Q565 I566 K567 V568 L668 M762 Y764 Q765 P786 K807
Binding residue
(residue number reindexed from 1)		F303 N441 Y444 A477 Q478 K479 K481 N508 S514 R515 T516 F555 Q558 I559 K560 V561 L655 M749 Y751 Q752 P773 K794
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lo5, PDBe:7lo5, PDBj:7lo5
PDBsum7lo5
PubMed33826880
UniProtA0A345IJ72

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