Structure of PDB 7lmb Chain A Binding Site BS01

Receptor Information
>7lmb Chain A (length=1012) Species: 5911 (Tetrahymena thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFL
TTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQI
GTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTK
VEQNGYLQVAGVCLNQYFSENQYIYPEIQRSQIFYCNHMGREPGVFKSSF
FNYSEPQTIIKKTLLKEYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNY
LLKKFCKLPENYQSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQ
ITNFLRQIIQNCVPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICF
MDVFDVEWFVDLKNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYN
FYITEKHKEGSQIFYYRKPIWKLVSKLTIVKLEEENLEKVEEKLIPEDSF
QKYPQGKLRIIPKKGSFRPIMTFLRKDKQKNIKLNLNQILMDSQLVFRNL
KDMLGQKIGYSVFDNKQISEKFAQFIEKWKNKGRPQLYYVTLDIKKCYDS
IDQMKLLNFFNQSDLIQDTYFINKYLLFQRNKRPLLQIMDNINFPYYFNL
KERQIAYSLYDDDDQILQKGFKEIQSDDRPFIVINQDKPRCITKDIIHNH
LKHISQYNVISFNKVKFRQKRGIPQGLNISGVLCSFYFGKLEEEYTQFLK
NAEQVNGSINLLMRLTDDYLFISDSQQNALNLIVQLQNCANNNGFMFNDQ
KITTNFQFPQEDYNLEHFKISVQNECQWIGKSIDMNTLEIKSIQKQTQQE
INQTINVAISIKNLKSQLKNKLRSLFLNQLIDYFNPNINSFEGLCRQLYH
HSKATVMKFYPFMTKLFQIDLKKSKQYSVQYGKENTNENFLKDILYYTVE
DVCKILCYLQFEDEINSNIKEIFKNLYSWIMWDIIVSYLKKKKQFKGYLN
KLLQKIRKSRFFYLKEGCKSLQLILSQQKYQLNKKELEAIEFIDLNNLIQ
DIKTLIPKISAK
Ligand information
>7lmb Chain B (length=151) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccgcuuaauucauucagaucuguaauagaacugucauucaaccccaaaa
gugcugauauaaccuucaccaauuagguucaaauaagugguaaugcggga
caaaagacuaucgacauuugauacacuauuuaucaauggaugucuuauuu
u
<<<<<..........<<<.<<<<...>>>>.>>>................
..........<<<<<..((((.((>>>>>.....)).))))...>>>>>.
....<<<<.<<<..<<.<<<<<<.......>>>>>>>>>>>>>>>.....
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lmb Structures of telomerase at several steps of telomere repeat synthesis.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		H234 M235 R237 P239 F242 K243 N324 Y325 K328 K332 L333 Y337 K341 Q382 L420 C424 Q444 K445 R446 K447 I449 S450 R453 R473 K497 K501 K532 I545 T547 L549 N656 K657 R658 P693 N776 K917 N918 I967 D968 K971 S972 K973 K990 Y994 Y995 E1019 K1038 Q1052 K1056 S1057 F1059 F1060 Y1061 K1063 K1101
Binding residue
(residue number reindexed from 1)		H188 M189 R191 P193 F196 K197 N249 Y250 K253 K257 L258 Y262 K266 Q307 L345 C349 Q369 K370 R371 K372 I374 S375 R378 R398 K422 K426 K457 I470 T472 L474 N581 K582 R583 P595 N678 K819 N820 I869 D870 K873 S874 K875 K892 Y896 Y897 E921 K940 Q954 K958 S959 F961 F962 Y963 K965 K1003
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0042162 telomeric DNA binding
GO:0046872 metal ion binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0007004 telomere maintenance via telomerase
Cellular Component
GO:0000333 telomerase catalytic core complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005697 telomerase holoenzyme complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lmb, PDBe:7lmb, PDBj:7lmb
PDBsum7lmb
PubMed33981033
UniProtO77448|TERT_TETTS Telomerase reverse transcriptase (Gene Name=TERT)

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