Structure of PDB 7lja Chain A Binding Site BS01

Receptor Information
>7lja Chain A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHP
CVSDQELGLLIKEVADALGGGADPETSHSAWDLGSAFFFSGTIITTIGYG
NVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIF
LKWHVPPELVRVLSEMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVI
VTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWL
RVV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7lja Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7lja Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK.
Resolution2.77 Å
Binding residue
(original residue number in PDB)		S112 D115 S118 D249
Binding residue
(residue number reindexed from 1)		S79 D82 S85 D216
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lja, PDBe:7lja, PDBj:7lja
PDBsum7lja
PubMed34390650
UniProtQ9NYG8|KCNK4_HUMAN Potassium channel subfamily K member 4 (Gene Name=KCNK4)

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