Structure of PDB 7lj5 Chain A Binding Site BS01

Receptor Information
>7lj5 Chain A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHP
CVSDQELGLLIKEVADALGGGADPETSHSAWDLGSAFFFSGTIITTIGYG
NVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIF
LKWHVPPELVRVLSEMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVI
VTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWL
RVV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7lj5 Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7lj5 Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		S112 D115 S118 D249
Binding residue
(residue number reindexed from 1)		S79 D82 S85 D216
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7lj5, PDBe:7lj5, PDBj:7lj5
PDBsum7lj5
PubMed34390650
UniProtQ9NYG8|KCNK4_HUMAN Potassium channel subfamily K member 4 (Gene Name=KCNK4)

[Back to BioLiP]