Structure of PDB 7liu Chain A Binding Site BS01

Receptor Information
>7liu Chain A (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSD
VEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAF
LLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYE
EARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERG
KIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSAT
FPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDL
LNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEAL
HQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGR
VGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7liu DDX3X bound to ATP analog and remodeled RNA:DNA hybrid
Resolution3.001 Å
Binding residue
(original residue number in PDB)		P274 T275 R276 G302 G303 T323 P324 G325 R326 D329 G356 F357 Q360 E449 T450 K451 H472 G473 R480 T498 A499 V500 E524
Binding residue
(residue number reindexed from 1)		P140 T141 R142 G168 G169 T189 P190 G191 R192 D195 G222 F223 Q226 E315 T316 K317 H338 G339 R346 T364 A365 V366 E390
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7liu, PDBe:7liu, PDBj:7liu
PDBsum7liu
PubMed
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

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