Structure of PDB 7lhz Chain A Binding Site BS01

Receptor Information
>7lhz Chain A (length=706) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWE
VSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIA
TLLCALFVRHFRTLVKEGHVYVALPPLYRIDLGKEVYYALTEEEKTGVLE
QLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLVISDEDEQQT
TAIMDMLLAKKRSEDRRNWLQEKGDMADERLALHEFTENAYLNYSMYVIM
DRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPH
GDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSK
YAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMA
TDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAEIITSRAE
IRKIYQNGRGSVRMRAVWSKEDGAVVITALPHQVSGAKVLEQIAAQMRNK
KLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRI
NLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHILE
GLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHLAK
LEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDDRR
SPLHER
Ligand information
Receptor-Ligand Complex Structure
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PDB7lhz Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		L446 N447 S459 H498 S613 R616 Y1018 Y1120 I1172 G1175 M1176 R1326
Binding residue
(residue number reindexed from 1)		L46 N47 S59 H98 S213 R216 Y241 Y343 I395 G398 M399 R549
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lhz, PDBe:7lhz, PDBj:7lhz
PDBsum7lhz
PubMed33929852
UniProtB5XU53;
B5XU60

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