Structure of PDB 7lfc Chain A Binding Site BS01

Receptor Information

>7lfc Chain A (length=414) Species: 9606 (Homo sapiens)

SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFF

Ligand information

>7lfc Chain B (length=12) Species: 9606 (Homo sapiens)

EEVQRKRQKLMP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lfc Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): K97 S100 D102 R103 P105 W137 N141 S144 G145 T150 Q176 W179 N183 G186 D187 N219 W222 N226 R229 R306
• Binding residue (residue number reindexed from 1): K26 S29 D31 R32 P34 W66 N70 S73 G74 T79 Q105 W108 N112 G115 D116 N148 W151 N155 R158 R235

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008139 nuclear localization sequence binding
• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus
• GO:0006607 NLS-bearing protein import into nucleus
• GO:0010467 gene expression
• GO:0014046 dopamine secretion
• GO:0015031 protein transport

Cellular Component

• GO:0005634 nucleus
• GO:0005643 nuclear pore
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0031965 nuclear membrane
• GO:0042564 NLS-dependent protein nuclear import complex

External links

• PDB: RCSB:7lfc, PDBe:7lfc, PDBj:7lfc
• PDBsum: 7lfc
• PubMed: 35260573
• UniProt: O00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)