Structure of PDB 7lcd Chain A Binding Site BS01

Receptor Information
>7lcd Chain A (length=427) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lcd Crystal structure of human polymerase eta complexed with syn N7-acetophenoneguanine
Resolution1.98 Å
Binding residue
(original residue number in PDB)		F18 Q38 Y39 W42 I48 W64 K86 R93 K293 K311 P316 K317 T318 G320 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		F18 Q38 Y39 W42 I48 W64 K86 R93 K288 K306 P311 K312 T313 G315 S317 K318 N319 P321 R346
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7lcd, PDBe:7lcd, PDBj:7lcd
PDBsum7lcd
PubMed
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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