Structure of PDB 7lc7 Chain A Binding Site BS01

Receptor Information
>7lc7 Chain A (length=178) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVLIHVCCAPDLLTTIFHVRDAEFFFYNPNIQPLSEYEKRREAVDKVAN
HFSLNVRYGEYSTEEIRKWYTAVKDYKLGEGSKRCERCISFLLERTAQEA
RKRGHESFSTTLLASPRKNLPMIENIGKTIEEKYGVKFFFKNFRKGGAYQ
EGVRLSKELGIYRQNYCGCVFSLLERRE
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7lc7 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7lc7 The epoxyqueuosine reductase QueH in the biosynthesis of tRNA queuosine is a unique metalloenzyme
Resolution1.58 Å
Binding residue
(original residue number in PDB)		R86 C87 C90 C169 C171
Binding residue
(residue number reindexed from 1)		R84 C85 C88 C167 C169
Annotation score1
Enzymatic activity
Enzyme Commision number 1.17.99.6: epoxyqueuosine reductase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0052693 epoxyqueuosine reductase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lc7, PDBe:7lc7, PDBj:7lc7
PDBsum7lc7
PubMed
UniProtQ9WZJ0|QUEH_THEMA Epoxyqueuosine reductase QueH (Gene Name=queH)

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