Structure of PDB 7lc5 Chain A Binding Site BS01

Receptor Information

>7lc5 Chain A (length=178) Species: 243274 (Thermotoga maritima MSB8)

TVLIHVCCAPDLLTTIFHVRDAEFFFYNPNIQPLSEYEKRREAVDKVANH
FSLNVRYGEYSTEEIRKWYTAVKDYKDLGEGSKRCERCISFLLERTAQEA
RKRGHESFSTTLLASPRKNLPMIENIGKTIEEKYGVKFFFKNFRKGGAYQ
EGVRLSKELGIYRQNYCGCVFSLLERRE

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 7lc5 Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lc5 Epoxyqueuosine Reductase QueH in the Biosynthetic Pathway to tRNA Queuosine Is a Unique Metalloenzyme.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): N32 E82 R86 C87 C90 C169 C171
• Binding residue (residue number reindexed from 1): N30 E80 R84 C85 C88 C167 C169
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.17.99.6: epoxyqueuosine reductase.

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding
• GO:0052693 epoxyqueuosine reductase activity

Biological Process

• GO:0006400 tRNA modification
• GO:0008033 tRNA processing
• GO:0008616 queuosine biosynthetic process

External links

• PDB: RCSB:7lc5, PDBe:7lc5, PDBj:7lc5
• PDBsum: 7lc5
• PubMed: 34652139
• UniProt: Q9WZJ0|QUEH_THEMA Epoxyqueuosine reductase QueH (Gene Name=queH)