Structure of PDB 7l3o Chain A Binding Site BS01

Receptor Information

>7l3o Chain A (length=400) Species: 353152 (Cryptosporidium parvum Iowa II)

RDHRLLGSNLQLFFFDSNVSPGSCFWLPAGARLYNKLMDFIRNEYRIREF
TEVITPNIFSCDLWKTSGHYFAYKENMFIFDVEEKEWGLKPMNCPGHCVM
FKHMNPSYRQLPIRLADFGVLHRNEFSGALNGLTRVRRFQQDDAHIFCTP
EQIQEEVFKALDFLFFIYGQLGFTFDLFLSTMPKEHLGTEEQWKEAENAL
KSALDKTGRDWKLNPGDGAFYGPKIDIMLWDALKRQHQCGTIQLDFQLPI
RFNLQYRTDELKQGYRRPVIIHRAILGSVERMSAVILEHTGGKLPFWLSP
RQAIVLSISEKTVEYAKSVERELCRRGFDVSGDYSAATINKKIRESQLLQ
WNYMLVIGENEARDKKVTLRCRDTTIPQELLTLDQLILKFSSMGFPSSID

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7l3o Chain A Residue 800

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7l3o Crystal Structure of the RNA binding domain of Threonyl-tRNA synthetase from Cryptosporidium parvum Iowa II
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): C426 H477 H629
• Binding residue (residue number reindexed from 1): C94 H145 H272
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.3: threonine--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004829 threonine-tRNA ligase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006418 tRNA aminoacylation for protein translation
• GO:0006435 threonyl-tRNA aminoacylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7l3o, PDBe:7l3o, PDBj:7l3o
• PDBsum: 7l3o
• UniProt: Q5CYN0