Structure of PDB 7ksf Chain A Binding Site BS01

Receptor Information
>7ksf Chain A (length=742) Species: 2170195 (Eastern chimpanzee simian foamy virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLLQPLPAEIKGTKLLAHWASGATITCIPESFLEDEQPIKKTLIKTEKQQ
NVYYVTFKVKGRKVEAEVIASPYEYILLSPTDVPWLTQQPLQLTILVPLQ
EYQEKILSKTALPEDQKQQLKTLFVKYDNLWQHWENQVGHRKIRPHNIAT
GDYPPRPQKQYPINPKAKPSIQIVIDDLLKQGVLTPQNSTMNTPVYPVPK
PDGRWRMVLDYREVNKTIPLTAAQNQHSAGILATIVRQKYKTTLDLANGF
WAHPITPESYWLTAFTWQGKQYCWTRLPQGFLNSPALFTADVVDLLKEIP
NVQVYVDDIYLSHDDPKEHVQQLEKVFQILLQAGYVVSLKKSEIGQKTVE
FLGFNITKEGRGLTDTFKTKLLNITPPKDLKQLQSILGLLNFARNFIPNF
AELVQPLYNLIASAKGKYIEWSEENTKQLNMVIEALNTASNLEERLPEQR
LVIKVNTSPSAGYVRYYNETGKKPIMYLNYVFSKAELKFSMLEKLLTTMH
KALIKAMDLAMGQEILVYSPIVSMTKIQKTPLPERKALPIRWITWMTYLE
DPRIQFHYDKTLPELKHIPDVYTSSQSPVKHPSQYEGVFYTDGSAIKSPD
PTKSNNAGMGIVHATYKPEYQVLNQWSIPLGNHTAQMAEIAAVEFACKKA
LKIPGPVLVITDSFYVAESANKELPYWKSNGFVNNKPLKHISKWKSIAEC
LSMKPDITIQHEKGHQPTNTSIHTEGNALADKLATQGSYVVN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7ksf Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ksf Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT).
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D601 G602 E648
Binding residue
(residue number reindexed from 1)		D592 G593 E639
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004190 aspartic-type endopeptidase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7ksf, PDBe:7ksf, PDBj:7ksf
PDBsum7ksf
PubMed34452360
UniProtA0A1Q1N9V8

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