Structure of PDB 7kr3 Chain A Binding Site BS01

Receptor Information
>7kr3 Chain A (length=632) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRPPPLTASGVFSKFRDIARLTGSAS
TAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSL
TPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPV
LLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKY
DGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPSVTSFILD
TEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGES
LVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSC
EGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRG
KRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPS
PRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGIS
LRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7kr3 High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.
Resolution2.778 Å
Binding residue
(original residue number in PDB)		H337 P341 A346 V349 G350 G352 G571 Q572 F635 F872
Binding residue
(residue number reindexed from 1)		H76 P80 A85 V88 G89 G91 G302 Q303 F366 F603
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7kr3, PDBe:7kr3, PDBj:7kr3
PDBsum7kr3
PubMed33473124
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

[Back to BioLiP]