Structure of PDB 7kqm Chain A Binding Site BS01

Receptor Information

>7kqm Chain A (length=596) Species: 7070 (Tribolium castaneum)

MVHYYRLSLKSRQKAPKIVNSKYNSILNIALKNFRLCKKHKTKKPVQILA
LLQEIIPKSYFGTTTNLKRFYKVVEKILTQSSFECIHLSVLHKCYDYDAI
PWLQNVEPNLRPKLLLKHNLFLLDNIVKPIIAFYYKPIKTLNGHEIKFIR
KEEYISFESKVFHKLKKMKYLVEVQDEVKPRGVLNIIPKQDNFRAIVSIF
PDSARKPFFKLLTSKIYKVLEEKYKTSGSLYTCWSEFTQKTQGQIYGIKV
DIRDAYGNVKIPVLCKLIQSIPTHLLDSEKKNFIVDHISNQFVAFRRKIY
KWNHGLLQGDPLSGCLCELYMAFMDRLYFSNLDKDAFIHRTVDDYFFCSP
HPHKVYDFELLIKGVYQVNPTKTRTNLPTHRHPQDEIPYCGKIFNLTTRQ
VRTLYKLPPNYEIRHKFKLWNFNNQISDDNPARFLQKAMDFPFICNSFTK
FEFNTVFNDQRTVFANFYDAMICVAYKFDAAMMALRTSFLVNDFGFIWLV
LSSTVRAYASRAFKKIVTYKGGKYRKVTFQCLKSIAWRAFLAVLKRRTEI
YKGLIDRIKSREKLTMKFHDGEVDASYFCKLPEKFRFVKINRKASI

Ligand information

>7kqm Chain B (length=17)

uccaggugcacaaagaa

.................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7kqm Flexibility of telomerase in binding the RNA template and DNA telomeric repeat.
• Resolution: 2.73 Å
• Binding residue (original residue number in PDB): K10 K139 L141 I187 I199 Y217 G309 P311 F441 C445 N446
• Binding residue (residue number reindexed from 1): K10 K139 L141 I187 I199 Y217 G309 P311 F441 C445 N446

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:7kqm, PDBe:7kqm, PDBj:7kqm
• PDBsum: 7kqm
• PubMed: 34969861
• UniProt: Q0QHL8