Structure of PDB 7kjv Chain A Binding Site BS01

Receptor Information
>7kjv Chain A (length=538) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPE
NPYNTPVFAWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDV
GDAYFSVPLDEDFRKYTAFTIPIRYQYNVLPQGWKGSPAIFQSSMTKILE
PFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDK
KHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDICKLVGKLNWASQ
IYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYY
DPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLT
EAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNT
PPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPL
TNTTNQKTQLQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVN
QIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIR
Ligand information
>7kjv Chain C (length=22) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggcgcccgaacagggacuuga
......................
Receptor-Ligand Complex Structure
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PDB7kjv High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D76 R448 N474 Q500 H539 R557
Binding residue
(residue number reindexed from 1)		D65 R429 N455 Q481 H520 R538
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7kjv, PDBe:7kjv, PDBj:7kjv
PDBsum7kjv
PubMed33947853
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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