Structure of PDB 7kcl Chain A Binding Site BS01

Receptor Information
>7kcl Chain A (length=612) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISN
ASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELV
SNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYS
RSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEAR
VRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVGEWQHEEFYRYVA
QAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVGSSVALYSRKVLIQ
TKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLI
KFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESS
ALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTE
VLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHCLSEKETEELMAWMR
NVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAKTQLLQPTL
EINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGR
LNELLVKALERH
Ligand information
>7kcl Chain C (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VIKDLVPDLSNFYAQYKSIEPYL
Receptor-Ligand Complex Structure
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PDB7kcl Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates
Resolution3.14 Å
Binding residue
(original residue number in PDB)		M352 V355 K382 E450 T454 L534 L537 H538 E614 H620 M624
Binding residue
(residue number reindexed from 1)		M283 V286 K309 E377 T381 L461 L464 H465 E527 H533 M537
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019901 protein kinase binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0009386 translational attenuation
GO:0060255 regulation of macromolecule metabolic process
GO:0061077 chaperone-mediated protein folding
GO:1901856 negative regulation of cellular respiration
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0071944 cell periphery

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kcl, PDBe:7kcl, PDBj:7kcl
PDBsum7kcl
PubMed
UniProtQ12931|TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (Gene Name=TRAP1)

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