Structure of PDB 7kbt Chain A Binding Site BS01

Receptor Information
>7kbt Chain A (length=1233) Species: 9606,9823 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIRRYYLGLSWDYRQSELLRELHDTRYKKTVFVEFTDQLFSVARPRPPWM
GLLGPTIQAEVYDTVVVTLKNMASHPVSLHAVGVSFWKSSEGAEYEDHTS
QREKEDDKVLPGKQTYVWQVLKENGPTASDPPCLTYSYLSHVDLVKDLNS
GLIGALLVCREGSLTRERTQNLHEFVLLFAVFDEGKSWHSAAQPAMHTVN
GYVNRSLPGLIGCHKKSVYWHVIGMGTSPEVHSIFLEGHTFLVRHHRQAS
LEISPLTFLTAQTFLMDLGQFLLFCHISSHHHGGMEAHVRVESCAEKHPK
TWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMA
YTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI
TDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLT
RYYSSFVNMERDLASGLIGPLLICYKSDKRNVILFSVFDENRSWYLTENI
QRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS
IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILG
CHNSDFRNRGMTALLKVSSCKRTRHYFIAAVEQLWDYGMSESPVPRFKKV
VFREFADGSFTQPSYRGELNKHLGLLGPYIRAEVEDNIMVTFKNQASRPY
SFYSSLISYPDDQEQGAEPRHNFVQPNETRTYFWKVQHHMAPTEDEFDCK
AWAYFSDVDLEKDVHSGLIGPLLICRANTLNAAHGRQVTVQEFALFFTIF
DETKSWYFTENVERNCTLKENYRFHAINGYVMDTLPGLVMAQNQRIRWYL
LSMGSNENIHSIHFSGHVFSVRKKEEYKMAVYNLYPGVFETVEMLPSKVG
IWRIECLIGEHLQAGMSTTFLVYSKKCQTPLGMASGHIRDFQITASGQYG
QWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFS
SLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPI
IARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASS
YFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVT
TQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVV
NSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain7kbt Chain A Residue 2402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7kbt Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor
Resolution4.15 Å
Binding residue
(original residue number in PDB)		H1954 I2002 H2005
Binding residue
(residue number reindexed from 1)		H860 I908 H911
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:7kbt, PDBe:7kbt, PDBj:7kbt
PDBsum7kbt
PubMed
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8);
P12263|FA8_PIG Coagulation factor VIII (Gene Name=F8)

[Back to BioLiP]