Structure of PDB 7k9m Chain A Binding Site BS01

Receptor Information
>7k9m Chain A (length=339) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALARQALAVLP
KEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLPST
RVPAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNFPADH
PARGEQDTFYIAPEDSRQLLRTHTSPVQIRTLLARELPVYIISIGRTFRT
DELDATHTPIFHQVEGLAVDRGLSMAHLRGTLDAFARAEFGPSARTRIRP
HFFPFTEPSAEVDVWFANKIGGAAWVEWGGCGMVHPNVLRATGIDPDLYS
GFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA
Ligand information
>7k9m Chain C (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguagcucagucgguaugagcguccgccugaaaagcggaaggucggcgg
uucgaucccgccccug
<<<..<<<<<.......>>>>>.<<<<<.......>>>>>.....<<<<<
.......>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB7k9m Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D37 Q46 L48 R56 A57 G60 K61 N64
Binding residue
(residue number reindexed from 1)		D35 Q44 L46 R54 A55 G58 K59 N62
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k9m, PDBe:7k9m, PDBj:7k9m
PDBsum7k9m
PubMed33885823
UniProtP9WFU3|SYFA_MYCTU Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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