Structure of PDB 7jl8 Chain A Binding Site BS01

Receptor Information
>7jl8 Chain A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNRKWEAKLKQIEERASEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALE
CKVGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFN
KPANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSR
HLIFQLHDVAFKDNIHVGNFLRKILQPALDLLPDLSFLVVKNNMGEKHLF
VDLGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFL
SSLVSNVRFSDTLRILTCEP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7jl8 Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H46 R47 Q48 G74 Q75 R76 Y78 T285 R286 R288
Binding residue
(residue number reindexed from 1)		H28 R29 Q30 G56 Q57 R58 Y60 T207 R208 R210
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jl8, PDBe:7jl8, PDBj:7jl8
PDBsum7jl8
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

[Back to BioLiP]