Structure of PDB 7jl0 Chain A Binding Site BS01

Receptor Information
>7jl0 Chain A (length=662) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKAS
EPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVV
KSCDIIISTAQILENSLLNLAGVQLSDFSLIIIDECHHTNKEAVYNNIMR
HYLMQKLKNNRLKKVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANL
DAFTIKTVKENLDQLKNQIQEPCKKFAIADREDPFKEKLLEIMTRIQTYC
QMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQIND
TIRMIDAYTHLETFYNEEKDKKFAVIEETDRFLMTLFFENNKMLKRLAEN
PEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEK
FAEVGVKAHHLIGAGSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEE
GLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIERE
TVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAK
HYNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVREKQ
INGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVE
LPITFPNLDYSE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7jl0 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		K450 E451 M926 H927 W1003
Binding residue
(residue number reindexed from 1)		K141 E142 M581 H582 W648
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7jl0, PDBe:7jl0, PDBj:7jl0
PDBsum7jl0
PubMed33373584
UniProtQ9BYX4|IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (Gene Name=IFIH1)

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