Structure of PDB 7jkp Chain A Binding Site BS01

Receptor Information
>7jkp Chain A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNRKWEAKLKQIEEEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALECKV
GDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKPA
NPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLI
FQLHDVAFKDNIHVGNFLRKILQPALDLLDLSFLVVKNNMGEKHLFVDLG
VYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFLSSLV
SNVRFSDTLRILTCEP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7jkp Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Resolution2.592 Å
Binding residue
(original residue number in PDB)		H46 R47 Q48 D73 G74 Q75 R76 Y78 R286
Binding residue
(residue number reindexed from 1)		H25 R26 Q27 D52 G53 Q54 R55 Y57 R204
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jkp, PDBe:7jkp, PDBj:7jkp
PDBsum7jkp
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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