Structure of PDB 7h4t Chain A Binding Site BS01

Receptor Information
>7h4t Chain A (length=140) Species: 31704 (Coxsackievirus A16) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGAIYVGNYRVVNRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARC
DCQTGVYYCSSRRKHYPVSFSKPSLIFVEASEYYPARYQSHLMLAVGHSE
PGDCGGILRCQHGVVGIVSTGGNGLVGFADVRDLLWLDEE
Ligand information
Ligand ID5SH
InChIInChI=1S/C11H9N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-9H
InChIKeyJVZRCNQLWOELDU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.4		c1ccc(cc1)c2ccncc2
FormulaC11 H9 N
Name4-phenylpyridine
ChEMBLCHEMBL109074
DrugBank
ZINCZINC000000967333
PDB chain7h4t Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7h4t Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease
Resolution1.69 Å
Binding residue
(original residue number in PDB)		T60 V62 R115 C116 Q117
Binding residue
(residue number reindexed from 1)		T54 V56 R109 C110 Q111
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016032 viral process

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Molecular Function
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Biological Process
External links
PDB RCSB:7h4t, PDBe:7h4t, PDBj:7h4t
PDBsum7h4t
PubMed
UniProtQ65900|POLG_CX16G Genome polyprotein

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