Structure of PDB 7h47 Chain A Binding Site BS01

Receptor Information
>7h47 Chain A (length=140) Species: 31704 (Coxsackievirus A16) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGAIYVGNYRVVNRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARC
DCQTGVYYCSSRRKHYPVSFSKPSLIFVEASEYYPARYQSHLMLAVGHSE
PGDCGGILRCQHGVVGIVSTGGNGLVGFADVRDLLWLDEE
Ligand information
Ligand IDZ5C
InChIInChI=1S/C6H8N2O3/c1-10-3-4-2-5(6(7)9)8-11-4/h2H,3H2,1H3,(H2,7,9)
InChIKeyXJISISZPFKFZEU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7COCc1cc(no1)C(=O)N
CACTVS 3.385COCc1onc(c1)C(N)=O
ACDLabs 12.01O=C(N)c1cc(COC)on1
FormulaC6 H8 N2 O3
Name5-(methoxymethyl)-1,2-oxazole-3-carboxamide
ChEMBL
DrugBank
ZINCZINC000085222241
PDB chain7h47 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7h47 Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease
Resolution1.01 Å
Binding residue
(original residue number in PDB)		N26 N30 S44 T45 T46
Binding residue
(residue number reindexed from 1)		N20 N24 S38 T39 T40
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016032 viral process

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Molecular Function
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Biological Process
External links
PDB RCSB:7h47, PDBe:7h47, PDBj:7h47
PDBsum7h47
PubMed
UniProtQ65900|POLG_CX16G Genome polyprotein

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