Structure of PDB 7g9x Chain A Binding Site BS01

Receptor Information
>7g9x Chain A (length=435) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKKRLRTVILAPTRVVAAEM
EEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLN
IMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSP
IMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLTKAGKR
VIQLSRKTFETEFQKTKNQEWDFVITTDISEMGANFKADRVIDSRRCLKP
VILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYMYGGGCAETDE
GHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTEQRKTF
VELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVPAEVWT
KYGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKR
Ligand information
Ligand IDZV5
InChIInChI=1S/C7H11N3O2/c11-5-7(10-6(12)9-5)2-1-3-8-4-7/h8H,1-4H2,(H2,9,10,11,12)/t7-/m1/s1
InChIKeyPLFDWSDBRBNQLQ-SSDOTTSWSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O=C1NC(=O)[C]2(CCCNC2)N1
OpenEye OEToolkits 2.0.7C1CC2(CNC1)C(=O)NC(=O)N2
OpenEye OEToolkits 2.0.7C1C[C@@]2(CNC1)C(=O)NC(=O)N2
ACDLabs 12.01O=C1NC(=O)NC21CCCNC2
CACTVS 3.385O=C1NC(=O)[C@]2(CCCNC2)N1
FormulaC7 H11 N3 O2
Name(5R)-1,3,7-triazaspiro[4.5]decane-2,4-dione
ChEMBL
DrugBank
ZINCZINC000022014935
PDB chain7g9x Chain A Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7g9x PanDDA analysis group deposition
Resolution1.809 Å
Binding residue
(original residue number in PDB)		G553 I554 D558 R560 R593
Binding residue
(residue number reindexed from 1)		G371 I372 D376 R378 R411
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7g9x, PDBe:7g9x, PDBj:7g9x
PDBsum7g9x
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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