Structure of PDB 7g9v Chain A Binding Site BS01

Receptor Information
>7g9v Chain A (length=435) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKKRLRTVILAPTRVVAAEM
EEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLN
IMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSP
IMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLTKAGKR
VIQLSRKTFETEFQKTKNQEWDFVITTDISEMGANFKADRVIDSRRCLKP
VILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYMYGGGCAETDE
GHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTEQRKTF
VELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVPAEVWT
KYGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKR
Ligand information
Ligand IDLHR
InChIInChI=1S/C9H9N3O/c1-6(13)11-8-3-2-7-5-10-12-9(7)4-8/h2-5H,1H3,(H,10,12)(H,11,13)
InChIKeyHOQHKYACTYMRFK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01CC(=O)Nc1ccc2cn[NH]c2c1
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CC(=O)Nc1ccc2cn[nH]c2c1
FormulaC9 H9 N3 O
NameN-(1H-indazol-6-yl)acetamide
ChEMBL
DrugBank
ZINCZINC000005291601
PDB chain7g9v Chain A Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7g9v PanDDA analysis group deposition
Resolution1.74 Å
Binding residue
(original residue number in PDB)		I434 G437 A516 A517 F522 W544
Binding residue
(residue number reindexed from 1)		I252 G255 A334 A335 F340 W362
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7g9v, PDBe:7g9v, PDBj:7g9v
PDBsum7g9v
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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