Structure of PDB 7g9l Chain A Binding Site BS01

Receptor Information
>7g9l Chain A (length=435) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKKRLRTVILAPTRVVAAEM
EEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLN
IMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSP
IMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLTKAGKR
VIQLSRKTFETEFQKTKNQEWDFVITTDISEMGANFKADRVIDSRRCLKP
VILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYMYGGGCAETDE
GHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTEQRKTF
VELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVPAEVWT
KYGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKR
Ligand information
Ligand IDZTQ
InChIInChI=1S/C15H14O3/c1-11(15(16)17)18-14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-11H,1H3,(H,16,17)/t11-/m0/s1
InChIKeyFUPGQEMJIGUBGO-NSHDSACASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CC(C(=O)O)Oc1ccc(cc1)c2ccccc2
OpenEye OEToolkits 2.0.7C[C@@H](C(=O)O)Oc1ccc(cc1)c2ccccc2
CACTVS 3.385C[CH](Oc1ccc(cc1)c2ccccc2)C(O)=O
CACTVS 3.385C[C@H](Oc1ccc(cc1)c2ccccc2)C(O)=O
ACDLabs 12.01CC(Oc1ccc(cc1)c1ccccc1)C(=O)O
FormulaC15 H14 O3
Name(2S)-2-[([1,1'-biphenyl]-4-yl)oxy]propanoic acid
ChEMBL
DrugBank
ZINCZINC000003063328
PDB chain7g9l Chain A Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7g9l PanDDA analysis group deposition
Resolution1.541 Å
Binding residue
(original residue number in PDB)		R242 M244 T245 T246
Binding residue
(residue number reindexed from 1)		R60 M62 T63 T64
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7g9l, PDBe:7g9l, PDBj:7g9l
PDBsum7g9l
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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