Structure of PDB 7foy Chain A Binding Site BS01

Receptor Information

>7foy Chain A (length=237) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GAMNSSNYAELFNNDIKLFVDDTNVYRVTVHKTFEGNVATKAINGCIFTL
NPKTGHLFLKIIHTSVWAGQKRLSQLAKWKTAEEVSALVRSLPKEEQPKQ
IIVTRKAMLDPLEVHMLDFPNIAIRPTELRLPFSAAMSIDKLSDVVMKAT
EPQMVLFNIYDDWLDRISSYTAFSRLTLLLRALKTNEESAKMILLSDPTI
TIKSYHLWPSFTDEQWITIESQMRDLILTEYGRKYNV

Ligand information

Ligand ID

W5C

InChI

InChI=1S/C11H11N3OS/c1-14-8-12-13-11(14)16-7-10(15)9-5-3-2-4-6-9/h2-6,8H,7H2,1H3

InChIKey

MQPQQMUJJODTTJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.385 OpenEye OEToolkits 2.0.7	Cn1cnnc1SCC(=O)c2ccccc2
ACDLabs 12.01	Cn1cnnc1SCC(=O)c1ccccc1

Formula

C11 H11 N3 O S

Name

2-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethan-1-one

PDB chain

7foy Chain A Residue 2101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7foy Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.
Resolution	1.55 Å
Binding residue (original residue number in PDB)	H1888 F1890 L1988 F1989
Binding residue (residue number reindexed from 1)	H56 F58 L156 F157
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0000398	mRNA splicing, via spliceosome

	Cellular Component
GO:0005681	spliceosomal complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:7foy, PDBe:7foy, PDBj:7foy
PDBsum	7foy
PubMed	36260741
UniProt	P33334\|PRP8_YEAST Pre-mRNA-splicing factor 8 (Gene Name=PRP8)

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