Structure of PDB 7fmy Chain A Binding Site BS01

Receptor Information
>7fmy Chain A (length=237) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAMNSSNYAELFNNDIKLFVDDTNVYRVTVHKTFEGNVATKAINGCIFTL
NPKTGHLFLKIIHTSVWAGQKRLSQLAKWKTAEEVSALVRSLPKEEQPKQ
IIVTRKAMLDPLEVHMLDFPNIAIRPTELRLPFSAAMSIDKLSDVVMKAT
EPQMVLFNIYDDWLDRISSYTAFSRLTLLLRALKTNEESAKMILLSDPTI
TIKSYHLWPSFTDEQWITIESQMRDLILTEYGRKYNV
Ligand information
Ligand IDVU9
InChIInChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
InChIKeyYZTJYBJCZXZGCT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01c1cc(ccc1)N1CCNCC1
CACTVS 3.385C1CN(CCN1)c2ccccc2
OpenEye OEToolkits 2.0.7c1ccc(cc1)N2CCNCC2
FormulaC10 H14 N2
Name1-phenylpiperazine
ChEMBLCHEMBL9434
DrugBank
ZINCZINC000000120271
PDB chain7fmy Chain A Residue 2101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7fmy Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		H1888 F1890 L1988
Binding residue
(residue number reindexed from 1)		H56 F58 L156
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0005681 spliceosomal complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7fmy, PDBe:7fmy, PDBj:7fmy
PDBsum7fmy
PubMed36260741
UniProtP33334|PRP8_YEAST Pre-mRNA-splicing factor 8 (Gene Name=PRP8)

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