Structure of PDB 7fhn Chain A Binding Site BS01

Receptor Information
>7fhn Chain A (length=647) Species: 3702,6100 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTPFQKAAALVDLAEDGIGLPVEILDQSSFGESARYYFIFTRLDLIWSLN
YFALLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVIT
LAILLVHTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYLLPF
RIAPYVRVIIFILSIRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIA
FVMFEATQQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVF
FVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLI
DSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKIN
KDEFADLCQAIALRFQKPSLFEHFPQIYHSALSQQLRAFVRSPNFGYAIS
FILIINFIAVVVETTLAIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYG
FENYWREGANRFDFLVTWVIVIGETATFITPDENTFFSNGAWIRYLLLAR
MLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVF
GGLVNAGNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWME
SYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFTELDLEEE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7fhn Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7fhn Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D39 D43 I45
Binding residue
(residue number reindexed from 1)		D12 D16 I18
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0008218 bioluminescence
GO:0009845 seed germination
GO:0010119 regulation of stomatal movement
GO:0019722 calcium-mediated signaling
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0080141 regulation of jasmonic acid biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005575 cellular_component
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7fhn, PDBe:7fhn, PDBj:7fhn
PDBsum7fhn
PubMed34845029
UniProtP42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP);
Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 (Gene Name=TPC1)

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