Structure of PDB 7f8x Chain A Binding Site BS01

Receptor Information

>7f8x Chain A (length=443) Species: 9606,10665

KEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVS
DLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTWNLVAIS
LERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFT
KNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLEL
YQGINIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELD
KAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRA
ALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAK
RVITTFRTGTWDAYAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRA
YDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLG

Ligand information

>7f8x Chain C (length=8) Species: 32630 (synthetic construct)

DFKGWKDF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7f8x Structures of the human cholecystokinin receptors bound to agonists and antagonists.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): F97 P101 N102 M121 Y176 M195 C196 R197 I563 F564 N567 R570 E578 L581 S582 I586 L590
• Binding residue (residue number reindexed from 1): F61 P65 N66 M85 Y140 M159 C160 R161 I392 F393 N396 R399 E407 L410 S411 I415 L419

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0044659 viral release from host cell by cytolysis

Cellular Component

• GO:0016020 membrane
• GO:0030430 host cell cytoplasm

External links

• PDB: RCSB:7f8x, PDBe:7f8x, PDBj:7f8x
• PDBsum: 7f8x
• PubMed: 34556863
• UniProt: P00720|ENLYS_BPT4 Endolysin (Gene Name=E);
  P32238|CCKAR_HUMAN Cholecystokinin receptor type A (Gene Name=CCKAR)