Structure of PDB 7f7o Chain A Binding Site BS01

Receptor Information
>7f7o Chain A (length=325) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHMLHLLEQIRAYCETCWEWQEAHMPAPVEHQICPAVCVLMKLSFDEEHR
HAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDV
ANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTL
REVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGAL
AFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQ
TLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHS
KHKMIAMGSAAALRNLMANRPAKYK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7f7o The tracer of FP assay for screening APC-Asef inhbitors
Resolution2.8 Å
Binding residue
(original residue number in PDB)		M503 F510 G511 K516 Q542 V543 R549 N550 W553 S587 S590 W593 N594 A597
Binding residue
(residue number reindexed from 1)		M90 F97 G98 K103 Q129 V130 R136 N137 W140 S174 S177 W180 N181 A184
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7f7o, PDBe:7f7o, PDBj:7f7o
PDBsum7f7o
PubMed
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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