Structure of PDB 7f7i Chain A Binding Site BS01
Receptor Information
>7f7i Chain A (length=182) Species:
10116
(Rattus norvegicus) [
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HYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYH
FVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVS
ANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLE
QEFTECFSAIVEGDSFEEIYHKVKRVIEDLSG
Ligand information
>7f7i Chain G (length=12) Species:
32630
(synthetic construct) [
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RIRRDEYLKAIQ
Receptor-Ligand Complex Structure
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PDB
7f7i
Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Resolution
2.595 Å
Binding residue
(original residue number in PDB)
D545 P564 R568 E574 Y580 E600 G602 Y604 Y609 G610 T611 D629
Binding residue
(residue number reindexed from 1)
D14 P33 R37 E43 Y49 E69 G71 Y73 Y78 G79 T80 D98
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7f7i
,
PDBe:7f7i
,
PDBj:7f7i
PDBsum
7f7i
PubMed
34458841
UniProt
P31016
|DLG4_RAT Disks large homolog 4 (Gene Name=Dlg4)
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