Structure of PDB 7f6m Chain A Binding Site BS01

Receptor Information
>7f6m Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHHHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICP
AVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLR
RYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVL
RNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAH
CTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIAT
NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEAL
WDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7f6m Discovery of Efficient Adenomatous Polyposis Coli - Rho Guanine Nucleotide Exchange Factor 4 Inhibitors by Employing High Binding Affinity Tracer
Resolution2.4 Å
Binding residue
(original residue number in PDB)		M503 N507 F510 G511 K516 Q542 V543 R549 N550 W553 S590 W593 N594 N641
Binding residue
(residue number reindexed from 1)		M105 N109 F112 G113 K118 Q144 V145 R151 N152 W155 S192 W195 N196 N243
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7f6m, PDBe:7f6m, PDBj:7f6m
PDBsum7f6m
PubMed
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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