Structure of PDB 7f5x Chain A Binding Site BS01

Receptor Information
>7f5x Chain A (length=236) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLE
GREVMMVTSGAVAFGKQKLAQELLMSLSMRPRAAAAVGQSGLMSLYDAMF
AQYGVKIAQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINTNDAVSP
DNDSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGAKLMHTYTSKVKAA
TWALDRGVSVVICNGMQEKAIKTIIGGRKVGTFFTE
Ligand information
Ligand IDGGL
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.2C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.2C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGAMMA-L-GLUTAMIC ACID;
L-GLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain7f5x Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7f5x Structural basis of dynamic P5CS filaments.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		S103 A105 N204 D207
Binding residue
(residue number reindexed from 1)		S59 A61 N143 D146
Annotation score5
Enzymatic activity
Enzyme Commision number 1.2.1.41: glutamate-5-semialdehyde dehydrogenase.
2.7.2.11: glutamate 5-kinase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004349 glutamate 5-kinase activity
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0016310 phosphorylation
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f5x, PDBe:7f5x, PDBj:7f5x
PDBsum7f5x
PubMed35286254
UniProtQ9VNW6

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