Structure of PDB 7ev1 Chain A Binding Site BS01

Receptor Information
>7ev1 Chain A (length=208) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPLKPMTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIEREGLL
YYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQ
SKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVM
YFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTT
SVDIIVTE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7ev1 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ev1 Mechanism of dimerization and structural features of human LI-cadherin.
Resolution1.38 Å
Binding residue
(original residue number in PDB)		N120 N122 D152 D154 N160 D215
Binding residue
(residue number reindexed from 1)		N92 N94 D124 D126 N132 D187
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ev1, PDBe:7ev1, PDBj:7ev1
PDBsum7ev1
PubMed34364873
UniProtQ12864|CAD17_HUMAN Cadherin-17 (Gene Name=CDH17)

[Back to BioLiP]