Structure of PDB 7euk Chain A Binding Site BS01

Receptor Information

>7euk Chain A (length=271) Species: 1914 (Streptomyces lavendulae)

MIDLIVSQGRVADRAAWMIEGAARTARALEERYGLKGHYVGEPAPHADDD
WSVALPQARETLVAVREAATESIKGDNLTVLVNNTCSVSLATLPVVAREH
PDAVVLYIDGHGDFNTPETTDTGYLGGMVLSGACGLWDSGHGAGLRPEQA
VLVGSRDIDEGERELIRKAGVRVIPPGEATAQAVLDAVKDAPVWIHIDWD
VLEPGSIPADYTVPDGMLPAQIRAVFEAIPAERLIGVELAELNAPADSER
AEQAVAVILDMVAPAFDAAAA

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 7euk Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7euk Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor.
• Resolution: 1.4 Å
• Binding residue (original residue number in PDB): C86 D109 D113 D198
• Binding residue (residue number reindexed from 1): C86 D109 D113 D198
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.3.25: N(omega)-hydroxy-L-arginine amidinohydrolase.

Gene Ontology

Molecular Function

• GO:0004053 arginase activity
• GO:0016787 hydrolase activity
• GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0017000 antibiotic biosynthetic process
• GO:0019547 arginine catabolic process to ornithine

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7euk, PDBe:7euk, PDBj:7euk
• PDBsum: 7euk
• PubMed: 35634777
• UniProt: D2Z025|DCSB_STRLA N(omega)-hydroxy-L-arginine amidinohydrolase (Gene Name=dcsB)