Structure of PDB 7eu0 Chain A Binding Site BS01

Receptor Information
>7eu0 Chain A (length=1060) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQVPVGTLTSIGFSISNNNDRDKMSVLEVEAPNQVTDSRLGLPNPDSVCR
TCGSKDRKVCEGHFGVINFAYSIINPYFLKEVAALLNKLGIDQRLIKKDI
PMFNSLGLTSFPVTPNGYRRTRIYKKLVGFEGNTLELSSRVMECMQYSRL
FSELCGLRFMKDVLLGKRSDHTFRTVVVGDPSLKLNEIGIPESIAKRLQV
SEHIFRSLMDGDTVLMNRPPSIHQHSLIAMTVRILPTTSVVSLNPICCLP
FRGDFDGDCLHGYVPQSIQAKVELDELVALDKQLINRQNGRNLLSLGQDS
LTAAYLVNVEKNCYLNRAQMQQLQMYCPFQLPPPAIIKASPSSTEPQWTG
MQLFGMLFPPGFDYTYPLNNVVVSNGELLSFSEGSAWLRDGEGNFIERLL
KHDKGKVLDIIYSAQEMLSQWLLMRGLSVSLADLYLSSDLQSRKNLTEEI
SYGLREAEQVCNKQQLMVESWRDFLAVNGEDKEEDSVSDLARFCYERQKS
ATLSELAVSAFKDAYRDVQALAYRYGDQSNSFLIMSKAGSKGNIGKLVQH
SMCIGLQNSAVSLSFGFPRELTCAAWNDPNSPLRGAKGKTTTESYVPYGV
IENSFLTGLNPLESFVHSVTSRDSSFSGNADLPGTLSRRLMFFMRDIYAA
YDGTVRNSFGNQLVQFTYETDGPVEDITGEALGSLSACALSEAAYSALDQ
PISLLETSPLLNLKNVLECGSKKGQREQTMSLYLSEYLSKKKHGFEYGSL
EIKNHLEKLSFSEIVSTSMIIFSPVPLSPWVCHFHISEKVLKRKQLSAES
VVSSLNEQYKSRNRELKLDIVDLDIQNTNHCSSDDQAMKDDNVCITVTVV
EASKHSVLELDAIRLVLIPFLLDSPVKGDQGIKKVNILWTDRPKAPKRNG
ELYLKVTMYGDRGKRNCWTALLECLPIMDMIDWGRSHPDNIRQCCSVYGI
DAGRSIFVANLESAVSDTGKEILREHLLLVADSLSVTGEFVALNAKGWSK
QRQVESTPAPFTQACFSSPSQCFLKAAKEGVRDDLQGSIDALAWGKVPGF
GTGDQFEIII
Ligand information
>7eu0 Chain O (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgagagguacuuuucuuuucuuucuucuucgg
................................
Receptor-Ligand Complex Structure
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PDB7eu0 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Resolution3.16 Å
Binding residue
(original residue number in PDB)		D447 D451 R709 Y716 K734 N736 S891
Binding residue
(residue number reindexed from 1)		D254 D258 R516 Y523 K541 N543 S696
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0010495 siRNA-mediated long-distance post-transcriptional gene silencing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
Cellular Component
GO:0000418 RNA polymerase IV complex
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7eu0, PDBe:7eu0, PDBj:7eu0
PDBsum7eu0
PubMed34941388
UniProtQ9LQ02|NRPD1_ARATH DNA-directed RNA polymerase IV subunit 1 (Gene Name=NRPD1)

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